Modulation by host of viral genome replication

Across TCGA patient cohorts, RNA activity of the Modulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TESPA1, PTGDS, and RFC5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral genome replication activity versus TESPA1 in PDAC (Pearson r = -0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TESPA1 →	-0.497	-0.215	.001	<.001	3	5
OV	PTGDS →	-1.020	-0.130	<.001	.008	2	6
HNSC	RFC5 →	+0.606	+0.150	<.001	<.001	3	5
GBM	SETDB1 →	+0.340	+0.173	<.001	.004	3	5
LUAD	SPAG5 →	+0.732	+0.163	<.001	.002	3	5
HNSC	LIG3 →	+0.709	+0.150	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044827 vs TESPA1 — PDAC

Explore this scatter interactively →