Modulation by host of viral genome replication

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral genome replication pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC22A18, MINDY3, and HLA-DPA1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC22A18 grouped by Modulation by host of viral genome replication-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SLC22A18 →	+1.426	+0.379	.006	.005	3	3
LUNG_NSCLC_LUAD	MINDY3 →	-0.606	-0.938	.006	<.001	3	3
LUNG_NSCLC_LUAD	HLA-DPA1 →	-1.970	-0.704	.002	.009	3	3
LUNG_NSCLC_LUAD	SYDE2 →	+0.553	+0.708	.009	.008	3	3
LUNG_NSCLC_LUSC	PSMC3 →	-0.807	-0.991	.005	.002	3	3
STOMACH	B4GALNT1 →	-2.966	-0.314	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC22A18 by Modulation by host of viral genome replication activity — BLOOD_Myeloma

Explore this box plot interactively →