Mitotic G2/M transition checkpoint

Across TCGA cell cohorts, RNA activity of the Mitotic G2/M transition checkpoint pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB4, RPS13, and RAD17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB4 grouped by Mitotic G2/M transition checkpoint-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMB4 →	+0.435	+0.157	.004	.003	3	6
LUNG_NSCLC_LUAD	RPS13 →	+0.201	+0.119	<.001	.005	3	6
LUNG_NSCLC_LUAD	RAD17 →	-0.290	-0.196	<.001	<.001	3	6
LUNG_NSCLC_LUAD	TOPBP1 →	-0.288	-0.218	<.001	<.001	3	6
PANCREAS	CHEK1 →	-0.359	-0.165	.004	.008	3	6
SKIN	RPS27A →	+0.239	+0.221	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB4 by Mitotic G2/M transition checkpoint activity — LUNG_SCLC

Explore this box plot interactively →