Nucleophagy

Across TCGA cell cohorts, RNA activity of the Nucleophagy pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATG3, ACOX1, and CCNH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleophagy activity versus ATG3 in LUNG_SCLC (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATG3 →	+0.687	+0.480	.004	<.001	3	7
URINARY_TRACT	ACOX1 →	-1.535	-0.414	.006	<.001	3	5
BLOOD_Lymphoma	CCNH →	+0.500	+0.536	.005	.007	3	5
BLOOD_Leukemia	SPRY2 →	+1.082	+0.552	.006	<.001	3	4
LUNG_NSCLC_LUAD	PCDH1 →	-2.414	-0.352	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	SNRPC →	+0.589	+0.478	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044804 vs ATG3 — LUNG_SCLC

Explore this scatter interactively →