Positive regulation by host of viral process

Across TCGA cell cohorts, RNA activity of the Positive regulation by host of viral process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHDC3, HOMER3, and TEX264, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral process activity versus KLHDC3 in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	KLHDC3 →	+0.979	+0.327	.005	.006	2	7
SKIN	HOMER3 →	-0.761	-0.139	.001	<.001	3	6
SKIN	TEX264 →	-0.666	-0.150	.003	.009	3	5
LIVER	SGMS2 →	-1.735	-0.375	.001	.001	3	5
OVARY	SLC9A7 →	-1.064	-0.266	<.001	<.001	3	5
LUNG_NSCLC_LUAD	ELOA →	+0.723	+0.227	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044794 vs KLHDC3 — STOMACH

Explore this scatter interactively →