Modulation by host of viral process

Across TCGA cell cohorts, RNA activity of the Modulation by host of viral process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARPC2, SETBP1, and TMEM255B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Modulation by host of viral process activity versus ARPC2 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ARPC2 →	-0.738	-0.128	.001	.002	3	6
STOMACH	SETBP1 →	+1.866	+0.213	.001	.001	3	5
SKIN	TMEM255B →	-1.575	-0.127	.005	.003	3	5
SKIN	HOMER3 →	-1.127	-0.163	.001	.004	3	5
OVARY	SQOR →	-2.858	-0.274	<.001	.001	3	5
BREAST	RPS6KA5 →	+1.331	+0.158	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044788 vs ARPC2 — BLOOD_Leukemia

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