Meiotic cell cycle phase transition

pathway activity — cross-omics
GO:0044771Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, RFC1_T506, and RFC2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADRFC1_S368 →+1.154+0.155<.001<.001310
LUADRFC1_T506 →+1.281+0.155<.001<.001310
LSCCRFC2 →+0.492+0.085<.001<.001310
LSCCRFC4 →+0.538+0.077<.001<.001310
LUADRPL12_S38 →+1.408+0.144<.001<.001310
HNSCRRM1 →+0.629+0.113<.001<.001310
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration