Response to human chorionic gonadotropin

Across TCGA patient cohorts, RNA activity of the Response to human chorionic gonadotropin pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN2, SNX9, and ARHGEF17, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to human chorionic gonadotropin activity versus CNN2 in BRCA (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNN2 →	+0.712	+0.091	<.001	<.001	3	8
OV	SNX9 →	+0.403	+0.078	<.001	<.001	3	8
COAD	ARHGEF17 →	+0.472	+0.065	<.001	<.001	3	8
BRCA	SYNC →	+0.598	+0.073	<.001	.001	3	7
UCEC	BRD2_S633 →	-0.741	-0.123	<.001	<.001	3	7
GBM	ELOA →	-0.230	-0.064	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044752 vs CNN2 — BRCA

Explore this scatter interactively →