Response to human chorionic gonadotropin

Across TCGA pan-cancer cohorts, RNA activity of the Response to human chorionic gonadotropin pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Response to human chorionic gonadotropin pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRC, UVM, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.913	0.811	<.001	95	view →
UVM	DFS	Median	II,III,IV	0.381	0.677	<.001	93	view →
SCLC	OS	Median	II,III,IV	0.523	0.839	<.001	77	view →
KIRP	OS	Median	All	0.820	0.934	.001	47	view →
STAD	OS	Median	All	0.346	0.666	<.001	47	view →
BRCA	DFS	Tertile	III,IV	0.886	0.725	.002	40	view →
LUAD	DFS	Median	All	0.214	0.451	<.001	37	view →
LGG	OS	Median	All	0.351	0.523	.001	25	view →
LAML	DFS	Tertile	All	0.339	0.648	.019	24	view →
ACC	DFS	Median	II,III,IV	0.186	0.782	.002	22	view →
HNSC	DFS	Tertile	III,IV	0.435	0.727	.005	21	view →
MESO	OS	Quartile	II,III,IV	0.274	0.561	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0044752–KIRC (DFS)

Open the KIRC breakdown →