Response to human chorionic gonadotropin

Across TCGA cell cohorts, RNA activity of the Response to human chorionic gonadotropin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELENOS, GJD3, and GSKIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SELENOS grouped by Response to human chorionic gonadotropin-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SELENOS →	-0.490	-0.506	.007	<.001	3	4
URINARY_TRACT	GJD3 →	-1.604	-0.409	<.001	<.001	3	3
SKIN	GSKIP →	-0.575	-0.714	.002	.001	2	4
SKIN	SPRED2 →	+0.506	+0.953	.001	.001	3	3
LARGE_INTESTINE	GEMIN5 →	+0.687	+0.525	<.001	.004	3	3
STOMACH	AP1G1 →	-0.827	-0.333	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SELENOS by Response to human chorionic gonadotropin activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →