Multi-multicellular organism process

Across TCGA cell cohorts, RNA activity of the Multi-multicellular organism process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNIH4, WWTR1, and RNF208, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multi-multicellular organism process activity versus CNIH4 in OVARY (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CNIH4 →	+0.579	+0.206	.001	.003	3	4
OVARY	WWTR1 →	+1.193	+0.208	.002	.001	3	4
OVARY	RNF208 →	-1.322	-0.193	.003	.007	3	4
OESOPHAGUS	TMEM156 →	+2.308	+0.326	.001	.002	3	4
LIVER	CD40 →	+2.696	+0.250	.004	.006	2	5
LIVER	FAM229B →	+2.405	+0.357	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044706 vs CNIH4 — OVARY

Explore this scatter interactively →