Tooth eruption

pathway activity — cross-omics
GO:0044691Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Tooth eruption pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UPP1, FCER1G, and HK3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVUPP1 →+0.861+0.141<.001<.00139
UCECFCER1G →+0.935+0.117<.001.00539
GBMHK3 →+0.950+0.109<.001<.00139
UCECNCF2 →+0.723+0.188<.001<.00139
GBMNCF4 →+0.683+0.127<.001<.00139
GBMHCK →+0.689+0.141<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration