Adhesion of symbiont to host cell

Across TCGA patient cohorts, RNA activity of the Adhesion of symbiont to host cell pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HIP1, HNRNPL, and LMCD1_S16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adhesion of symbiont to host cell activity versus HIP1 in LUAD (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HIP1 →	+0.484	+0.123	<.001	<.001	3	7
GBM	HNRNPL →	-0.198	-0.105	.001	<.001	3	7
PDAC	LMCD1_S16 →	+0.991	+0.078	<.001	<.001	3	7
BRCA	PLXDC2 →	+0.432	+0.073	<.001	<.001	3	7
PDAC	LIX1L →	+0.357	+0.074	<.001	<.001	3	7
BRCA	LRP1 →	+0.460	+0.073	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044650 vs HIP1 — LUAD

Explore this scatter interactively →