[2Fe-2S] cluster assembly

Across TCGA patient cohorts, RNA activity of the [2Fe-2S] cluster assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB22, BCL6B, and MEA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, [2Fe-2S] cluster assembly activity versus ZBTB22 in CCRCC (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZBTB22 →	-0.268	-0.091	<.001	.006	3	4
LSCC	BCL6B →	-0.436	-0.194	.005	.003	3	4
COAD	MEA1 →	-0.425	-0.106	.001	.002	3	3
CCRCC	CMTR1 →	-0.166	-0.119	.003	<.001	3	3
GBM	LMO4 →	-0.537	-0.160	<.001	<.001	3	3
CCRCC	SNAPIN →	-0.184	-0.127	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044571 vs ZBTB22 — CCRCC

Explore this scatter interactively →