Relaxation of smooth muscle

Across TCGA patient cohorts, RNA activity of the Relaxation of smooth muscle pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCAN2, NAP1L3, and RHOJ, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Relaxation of smooth muscle activity versus RCAN2 in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RCAN2 →	+1.027	+0.190	<.001	<.001	3	6
GBM	NAP1L3 →	+0.620	+0.160	.004	.004	3	6
LSCC	RHOJ →	+0.584	+0.331	<.001	.001	3	6
GBM	PDE1A →	+0.760	+0.174	<.001	<.001	3	5
GBM	SGIP1 →	+0.635	+0.232	.001	<.001	3	5
COAD	CASQ2 →	+1.070	+0.100	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044557 vs RCAN2 — GBM

Explore this scatter interactively →