Relaxation of smooth muscle

Across TCGA cell cohorts, RNA activity of the Relaxation of smooth muscle pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NECAB2, H2BC18, and LTB4R, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NECAB2 grouped by Relaxation of smooth muscle-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NECAB2 →	+0.434	+0.593	.005	<.001	3	3
BREAST	H2BC18 →	+0.886	+0.551	.005	.001	3	3
BREAST	LTB4R →	+1.131	+0.800	.001	.002	3	3
CNS	AGO4 →	+0.539	+0.701	<.001	<.001	3	3
LUNG_NSCLC_LUSC	INTS9 →	-0.614	-0.974	.004	.005	3	3
BLOOD_Myeloma	DDOST →	-0.770	-0.965	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NECAB2 by Relaxation of smooth muscle activity — BREAST

Explore this box plot interactively →