Regulation of mitochondrial mRNA stability

Across TCGA cell cohorts, RNA activity of the Regulation of mitochondrial mRNA stability pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf50, ZNF280D, and MCRIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial mRNA stability activity versus C1orf50 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C1orf50 →	-0.761	-0.257	.001	.002	3	5
LUNG_NSCLC_LUSC	ZNF280D →	-0.812	-1.066	.002	.003	3	5
LUNG_NSCLC_LUAD	MCRIP2 →	+0.733	+0.704	<.001	<.001	3	4
KIDNEY	RTTN →	-1.364	-1.243	<.001	<.001	3	4
SKIN	TSC22D3 →	-1.486	-0.914	.007	.004	2	5
SKIN	RPP14 →	+0.704	+0.880	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044528 vs C1orf50 — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →