Motile cilium assembly

Across TCGA patient cohorts, RNA activity of the Motile cilium assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR54, IFT122, and LZTFL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Motile cilium assembly activity versus WDR54 in UCEC (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR54 →	+0.614	+0.114	<.001	<.001	3	8
UCEC	IFT122 →	+0.430	+0.119	<.001	<.001	3	8
BRCA	LZTFL1 →	+0.594	+0.050	<.001	<.001	3	8
UCEC	OSCP1 →	+0.822	+0.118	<.001	<.001	3	8
UCEC	WDR19 →	+0.468	+0.118	<.001	<.001	3	7
UCEC	CETN2 →	+0.515	+0.115	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044458 vs WDR54 — UCEC

Explore this scatter interactively →