Motile cilium assembly

Across TCGA cell cohorts, RNA activity of the Motile cilium assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLDN14, ZNF568, and STAMBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLDN14 grouped by Motile cilium assembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLDN14 →	+0.312	+0.309	.001	<.001	3	4
LUNG_NSCLC_LUSC	ZNF568 →	-0.136	-0.316	.007	.006	3	3
KIDNEY	STAMBP →	+0.360	+1.738	.007	<.001	3	3
STOMACH	CACNA1B →	+0.262	+0.335	.003	.007	3	3
STOMACH	NIPA2 →	-0.247	-0.330	.004	.009	3	3
SKIN	OTOP1 →	+0.163	+0.363	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLDN14 by Motile cilium assembly activity — LUNG_SCLC

Explore this box plot interactively →