Symbiont entry into host

Across TCGA cell cohorts, RNA activity of the Symbiont entry into host pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUAK2, MAP4, and EHD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Symbiont entry into host activity versus NUAK2 in BLOOD_Myeloma (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NUAK2 →	+1.847	+0.265	.004	.001	3	6
LARGE_INTESTINE	MAP4 →	+0.620	+0.218	.002	<.001	3	6
BREAST	EHD2 →	+2.669	+0.237	.002	.001	3	6
BREAST	SERPINE2 →	+3.326	+0.263	<.001	<.001	3	6
BREAST	RRAS2 →	+2.823	+0.259	<.001	.001	3	5
LUNG_SCLC	GPR176 →	+1.988	+0.189	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044409 vs NUAK2 — BLOOD_Myeloma

Explore this scatter interactively →