Adhesion of symbiont to host

Across TCGA patient cohorts, RNA activity of the Adhesion of symbiont to host pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CALD1_S73, DCHS1, and GSN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adhesion of symbiont to host activity versus CALD1_S73 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CALD1_S73 →	+0.711	+0.081	<.001	<.001	3	7
HNSC	DCHS1 →	+0.621	+0.110	.001	<.001	3	7
GBM	GSN →	+0.490	+0.062	<.001	.005	3	7
BRCA	ISLR →	+0.631	+0.079	<.001	<.001	3	7
BRCA	COL6A3_S162 →	+0.751	+0.087	<.001	<.001	3	6
COAD	CTHRC1 →	+0.687	+0.042	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044406 vs CALD1_S73 — LUAD

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