Adhesion of symbiont to host

Across TCGA cell cohorts, RNA activity of the Adhesion of symbiont to host pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED5, OSTM1, and SMPD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adhesion of symbiont to host activity versus TMED5 in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TMED5 →	+1.048	+0.364	.001	<.001	3	6
BREAST	OSTM1 →	+1.013	+0.240	.004	<.001	3	6
BLOOD_Lymphoma	SMPD1 →	+1.971	+0.219	<.001	.001	3	5
KIDNEY	MINPP1 →	+1.057	+0.403	.005	<.001	3	4
BREAST	TMED7 →	+0.729	+0.144	.003	.007	3	4
BREAST	MMEL1 →	-1.289	-0.162	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044406 vs TMED5 — LIVER

Explore this scatter interactively →