Glucose import in response to insulin stimulus

Across TCGA patient cohorts, RNA activity of the Glucose import in response to insulin stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TPX2_S738, CD38, and FOXN3_S448, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucose import in response to insulin stimulus activity versus TPX2_S738 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPX2_S738 →	-0.642	-0.084	<.001	<.001	3	5
LSCC	CD38 →	-0.571	-0.051	.001	.002	3	5
UCEC	FOXN3_S448 →	-0.459	-0.094	<.001	.001	3	5
BRCA	SLC2A4_S488 →	-0.831	-0.048	.007	.006	2	6
HNSC	ITGB4_S1483 →	+1.201	+0.080	<.001	.004	3	5
LUAD	SH3RF1 →	+0.321	+0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044381 vs TPX2_S738 — GBM

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