Glucose import in response to insulin stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Glucose import in response to insulin stimulus pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 6 member genes.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher Glucose import in response to insulin stimulus pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as OV and UCEC, show the opposite pattern, with higher activity associated with better survival.

READ, BLCA, and OV are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.755	0.993	.002	50	view →
BLCA	DFS	Median	III,IV	0.226	0.454	.007	43	view →
OV	OS	Quartile	All	0.903	0.796	.003	42	view →
LGG	DFS	Median	All	0.762	0.889	<.001	41	view →
UCEC	OS	Quartile	All	0.965	0.889	.001	30	view →
UVM	DFS	Tertile	All	0.356	0.877	.001	26	view →
KIRC	DFS	Median	All	0.550	0.671	.004	26	view →
LUSC	DFS	Tertile	All	0.293	0.495	.002	23	view →
SKCM	OS	Tertile	All	0.440	0.282	.007	19	view →
SCLC	OS	Tertile	All	0.447	1.000	.011	17	view →
LIHC	DFS	Median	III,IV	0.450	0.297	.016	9	view →
CHOL	DFS	Tertile	III,IV	0.163	0.529	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0044381–READ (OS)

Open the READ breakdown →