Protein localization to cytoskeleton

Across TCGA patient cohorts, RNA activity of the Protein localization to cytoskeleton pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPCEF1, ZNF683, and HMGN2P46, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to cytoskeleton activity versus IPCEF1 in BRCA (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IPCEF1 →	-0.377	-0.618	<.001	<.001	3	4
OV	ZNF683 →	-0.923	-0.375	.001	<.001	3	3
OV	HMGN2P46 →	+0.673	+0.408	<.001	<.001	3	3
BRCA	TRBV24-1 →	-0.892	-0.698	<.001	.002	3	3
OV	CNOT7P2 →	+0.349	+0.389	.006	.002	3	3
BRCA	C11orf21 →	-0.739	-0.624	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044380 vs IPCEF1 — BRCA

Explore this scatter interactively →