Macropinocytosis

Across TCGA cell cohorts, RNA activity of the Macropinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HCCS, SERPINE2, and EIF3I, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HCCS grouped by Macropinocytosis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HCCS →	-1.053	-2.183	.003	.008	2	5
PANCREAS	SERPINE2 →	-2.664	-1.077	.006	.006	3	4
PANCREAS	EIF3I →	-0.665	-1.231	.004	.005	3	4
LUNG_NSCLC_LUSC	SKI →	-1.027	-1.240	<.001	.008	3	4
SOFT_TISSUE	ICAM4 →	-1.164	-1.118	.004	.001	3	3
LIVER	MRPL20 →	-0.903	-1.327	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HCCS by Macropinocytosis activity — BLOOD_Lymphoma

Explore this box plot interactively →