Type B pancreatic cell proliferation

Across TCGA patient cohorts, RNA activity of the Type B pancreatic cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, EFNB2, and CNIH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Type B pancreatic cell proliferation activity versus IRS2 in LUAD (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRS2 →	+1.149	+0.618	<.001	<.001	3	8
COAD	EFNB2 →	+0.589	+0.702	<.001	<.001	3	4
GBM	CNIH3 →	+0.791	+0.198	.001	.001	3	4
LUAD	DDIT4L →	+0.957	+0.457	.004	.001	3	4
COAD	COG6 →	+0.405	+0.747	<.001	.002	3	4
GBM	PACSIN1 →	-1.097	-0.180	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044342 vs IRS2 — LUAD

Explore this scatter interactively →