Type B pancreatic cell proliferation

Across TCGA cell cohorts, RNA activity of the Type B pancreatic cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIT1, ZC3H7A, and AAAS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NIT1 grouped by Type B pancreatic cell proliferation-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	NIT1 →	+0.588	+0.983	.007	.002	3	4
SKIN	ZC3H7A →	+0.670	+0.415	.006	.005	2	5
SKIN	AAAS →	-0.318	-0.365	.005	.003	3	4
LUNG_NSCLC_LUAD	HPS3 →	+0.667	+0.346	.001	<.001	3	3
SOFT_TISSUE	ZNF660 →	+1.276	+1.085	.001	.007	3	3
SOFT_TISSUE	BMT2 →	+0.687	+0.671	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NIT1 by Type B pancreatic cell proliferation activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →