Sodium-dependent phosphate transport

Across TCGA patient cohorts, RNA activity of the Sodium-dependent phosphate transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, ASPN, and BGN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium-dependent phosphate transport activity versus RSU1 in COAD (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RSU1 →	+0.535	+0.095	<.001	<.001	3	9
OV	ASPN →	+1.367	+0.115	<.001	<.001	3	9
HNSC	BGN →	+0.733	+0.102	<.001	.003	3	9
BRCA	DCN →	+0.830	+0.073	<.001	<.001	3	9
COAD	ILK →	+0.555	+0.090	<.001	<.001	3	9
OV	LUM →	+0.831	+0.092	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044341 vs RSU1 — COAD

Explore this scatter interactively →