Sodium-dependent phosphate transport

Across TCGA patient cohorts, RNA activity of the Sodium-dependent phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAP, CCN4, and SFRP4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sodium-dependent phosphate transport activity versus FAP in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAP →	+1.302	+0.343	<.001	<.001	3	5
LSCC	CCN4 →	+1.060	+0.287	<.001	<.001	3	5
LSCC	SFRP4 →	+1.643	+0.337	<.001	<.001	3	5
LSCC	VCAN →	+1.213	+0.340	<.001	<.001	2	6
LUAD	TNFSF4 →	+0.365	+0.230	.003	.002	3	5
HNSC	TGFB3 →	+0.606	+0.457	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044341 vs FAP — LSCC

Explore this scatter interactively →