Sodium-dependent phosphate transport

Across TCGA cell cohorts, RNA activity of the Sodium-dependent phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1A, MET, and SPATS2L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERO1A grouped by Sodium-dependent phosphate transport-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ERO1A →	-1.038	-0.878	.001	.005	3	5
OVARY	MET →	-2.460	-0.983	.006	.006	2	5
LUNG_SCLC	SPATS2L →	-2.373	-0.848	<.001	.005	3	4
CNS	CCP110 →	+0.626	+0.813	<.001	<.001	3	4
BLOOD_Lymphoma	FRRS1 →	-1.825	-1.844	.006	.004	3	4
LUNG_NSCLC_LUAD	AGRN →	-0.917	-0.844	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERO1A by Sodium-dependent phosphate transport activity — PANCREAS

Explore this box plot interactively →