Cell-cell adhesion mediated by cadherin

Across TCGA cell cohorts, RNA activity of the Cell-cell adhesion mediated by cadherin pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3orf52, SERPINB1, and SMIM10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-cell adhesion mediated by cadherin activity versus C3orf52 in SOFT_TISSUE (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C3orf52 →	+2.534	+0.603	.003	<.001	3	6
BONE	SERPINB1 →	+3.380	+0.775	<.001	.001	3	6
BONE	SMIM10 →	+2.938	+0.540	<.001	.002	3	6
BLOOD_Lymphoma	PRKAA1 →	+0.769	+0.810	<.001	<.001	3	6
BLOOD_Lymphoma	NPTN →	+1.036	+0.673	<.001	.004	3	6
OVARY	PDAP1 →	+0.556	+0.183	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044331 vs C3orf52 — SOFT_TISSUE

Explore this scatter interactively →