Response to leptin

Across TCGA patient cohorts, RNA activity of the Response to leptin pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC70, ANKAR, and RORA, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to leptin activity versus LRRC70 in MESO (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	LRRC70 →	+0.449	+0.055	.001	<.001	3	27
UVM	ANKAR →	+0.499	+0.053	<.001	<.001	3	25
THYM	RORA →	+0.997	+0.066	<.001	<.001	3	25
UVM	CLK1 →	+1.446	+0.050	<.001	<.001	3	24
THYM	KLF10 →	+1.095	+0.061	<.001	<.001	3	24
UVM	CCNL1 →	+1.134	+0.048	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044321 vs LRRC70 — MESO

Explore this scatter interactively →