Response to leptin

Across TCGA cell cohorts, RNA activity of the Response to leptin pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCND1, MAB21L4, and HSH2D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCND1 grouped by Response to leptin-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CCND1 →	+1.405	+0.400	<.001	.009	3	5
LUNG_NSCLC_LUAD	MAB21L4 →	+1.541	+0.452	.002	<.001	3	4
LUNG_NSCLC_LUAD	HSH2D →	+1.183	+0.396	.001	.001	3	4
KIDNEY	AKTIP →	+0.871	+0.809	<.001	.008	3	4
UPPER_AERODIGESTIVE_TRACT	SLC22A5 →	-1.143	-0.376	.008	.002	3	4
LARGE_INTESTINE	ABCC10 →	+0.721	+0.925	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCND1 by Response to leptin activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →