Protein K27-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K27-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC150, FOXM1, and NEK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K27-linked ubiquitination activity versus CCDC150 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCDC150 →	+0.707	+0.728	<.001	.001	3	6
BRCA	FOXM1 →	+0.749	+0.571	<.001	<.001	3	5
LUAD	NEK2 →	+0.975	+0.233	<.001	<.001	3	5
BRCA	NUF2 →	+1.121	+0.838	<.001	<.001	3	5
LSCC	H4C3 →	+0.813	+0.699	<.001	<.001	3	5
LSCC	H4C2 →	+0.698	+0.626	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044314 vs CCDC150 — BRCA

Explore this scatter interactively →