Protein K27-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K27-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBXO7, SOCS2, and HMGXB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FBXO7 grouped by Protein K27-linked ubiquitination-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FBXO7 →	-0.772	-0.277	.006	.004	2	5
BREAST	SOCS2 →	-1.460	-0.237	.004	.003	3	4
BLOOD_Myeloma	HMGXB4 →	-0.713	-0.235	<.001	<.001	3	4
BLOOD_Myeloma	ACO2 →	-1.085	-0.276	.008	<.001	3	4
BLOOD_Myeloma	TRAPPC8 →	-0.766	-0.227	.001	<.001	3	4
OVARY	WASHC4 →	-0.759	-0.167	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FBXO7 by Protein K27-linked ubiquitination activity — BLOOD_Myeloma

Explore this box plot interactively →