Protein K27-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K27-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHCHD3, MPP1, and ABCF2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K27-linked ubiquitination activity versus CHCHD3 in URINARY_TRACT (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CHCHD3 →	+0.727	+1.349	.002	.004	3	5
LUNG_NSCLC_LUSC	MPP1 →	+3.295	+2.047	.001	<.001	3	5
LIVER	ABCF2 →	+0.635	+1.320	<.001	.004	3	5
STOMACH	ITGB5 →	-1.641	-0.984	.004	.005	3	4
URINARY_TRACT	GID8 →	-0.658	-1.372	.006	.003	3	4
URINARY_TRACT	ESRP2 →	-2.817	-1.429	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044314 vs CHCHD3 — URINARY_TRACT

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