Protein K27-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K27-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UBE2S, HSPA8, and CAPRIN1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K27-linked ubiquitination activity versus UBE2S in STOMACH (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	UBE2S →	+1.799	+2.154	.003	<.001	2	13
LUNG_NSCLC_LUSC	HSPA8 →	+0.882	+1.826	<.001	<.001	3	11
STOMACH	CAPRIN1 →	+1.197	+1.472	.006	<.001	3	10
STOMACH	CCT5 →	+1.227	+1.536	.003	.001	3	10
STOMACH	RPS14 →	+1.091	+1.506	<.001	<.001	3	10
LIVER	MAT2A →	+2.228	+1.565	.006	.004	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044314 vs UBE2S — STOMACH

Explore this scatter interactively →