Sulfur compound catabolic process

Across TCGA patient cohorts, RNA activity of the Sulfur compound catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GEMIN2, PRMT5, and WDR74, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sulfur compound catabolic process activity versus GEMIN2 in GBM (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GEMIN2 →	-0.389	-0.116	<.001	.001	3	5
GBM	PRMT5 →	-0.382	-0.134	<.001	.002	3	4
CCRCC	WDR74 →	-0.212	-0.134	.004	.002	3	4
PDAC	VPS72 →	-0.175	-0.109	.008	<.001	2	5
PDAC	GPANK1 →	-0.262	-0.119	.001	.006	3	4
CCRCC	ZNF143 →	-0.181	-0.163	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044273 vs GEMIN2 — GBM

Explore this scatter interactively →