Sulfur compound biosynthetic process

Across TCGA cell cohorts, RNA activity of the Sulfur compound biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED26, WRN, and TET2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED26 grouped by Sulfur compound biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MED26 →	-0.649	-0.203	.002	.001	2	6
LUNG_SCLC	WRN →	-1.066	-0.160	<.001	.005	3	4
LUNG_SCLC	TET2 →	-1.082	-0.164	<.001	.004	3	4
PANCREAS	PYGL →	-2.776	-0.254	.004	.006	2	5
SOFT_TISSUE	ABCA1 →	-2.401	-1.306	.002	.001	3	4
STOMACH	POC1B →	+1.085	+0.174	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED26 by Sulfur compound biosynthetic process activity — STOMACH

Explore this box plot interactively →