Sulfur compound biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Sulfur compound biosynthetic process pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 159 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Sulfur compound biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and LUAD, show the opposite pattern, with higher activity associated with better survival.

LGG, LIHC, and CHOL are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Tertile	All	0.611	0.798	<.001	54	view →
LIHC	DFS	Quartile	All	0.162	0.470	.001	36	view →
CHOL	OS	Quartile	II,III,IV	0.087	0.901	.003	33	view →
PAAD	OS	Quartile	II,III,IV	0.640	0.355	.007	18	view →
KIRP	DFS	Median	III,IV	0.131	0.734	.001	18	view →
SCLC	DFS	Tertile	II,III,IV	0.298	0.640	.010	16	view →
LUAD	OS	Median	All	0.531	0.282	.022	10	view →
PRAD	DFS	Quartile	All	0.959	0.886	.026	6	view →
STAD	OS	Quartile	IV	1.000	0.380	.027	6	view →
ESCA	DFS	Median	III,IV	0.448	0.242	.021	5	view →
HNSC	DFS	Tertile	IV	0.528	0.347	.032	5	view →
OV	OS	Quartile	III,IV	0.745	0.854	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0044272–LGG (DFS)

Open the LGG breakdown →