Regulation of monoatomic anion transport

Across TCGA patient cohorts, RNA activity of the Regulation of monoatomic anion transport pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALD1, LTBP1, and PLOD3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of monoatomic anion transport activity versus PALD1 in COAD (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PALD1 →	+0.422	+0.059	.004	<.001	3	5
GBM	LTBP1 →	+0.331	+0.046	.001	.001	3	5
GBM	PLOD3 →	+0.721	+0.085	<.001	<.001	3	5
CCRCC	TES_S168 →	+0.426	+0.076	.002	<.001	3	4
CCRCC	TNC →	+0.749	+0.068	<.001	<.001	3	4
GBM	VRK3_S136 →	-0.507	-0.073	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044070 vs PALD1 — COAD

Explore this scatter interactively →