Regulation of monoatomic anion transport

Across TCGA cell cohorts, RNA activity of the Regulation of monoatomic anion transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G3BP1, ANKHD1, and ZNF552, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, G3BP1 grouped by Regulation of monoatomic anion transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	G3BP1 →	+0.174	+0.647	<.001	.007	3	3
LUNG_SCLC	ANKHD1 →	-0.142	-1.392	.008	.007	3	3
BONE	ZNF552 →	+0.285	+0.323	.003	<.001	3	2
BONE	ELANE →	+0.296	+0.320	.004	.006	3	2
LUNG_NSCLC_LUAD	SLC29A1 →	-0.102	-0.521	<.001	.006	3	2
URINARY_TRACT	MATN1 →	+0.115	+1.402	.008	.002	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

G3BP1 by Regulation of monoatomic anion transport activity — OVARY

Explore this box plot interactively →