Regulation of respiratory system process

Across TCGA cell cohorts, RNA activity of the Regulation of respiratory system process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GOLGA6L4, MCM4, and PRKDC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GOLGA6L4 grouped by Regulation of respiratory system process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GOLGA6L4 →	-0.911	-1.846	.002	<.001	3	4
BLOOD_Leukemia	MCM4 →	+1.043	+1.419	<.001	<.001	3	3
BLOOD_Leukemia	PRKDC →	+0.928	+1.211	.002	.001	3	3
SKIN	ZNFX1 →	+0.887	+1.099	.001	<.001	3	3
SKIN	TRIP10 →	+0.509	+0.738	.002	.003	3	3
SKIN	CPA4 →	+1.905	+0.737	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GOLGA6L4 by Regulation of respiratory system process activity — SOFT_TISSUE

Explore this box plot interactively →