Regulation of respiratory system process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of respiratory system process pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 15 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Regulation of respiratory system process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ESCA and SKCM, show the opposite pattern, with higher activity associated with better survival.

KIRC, COAD, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.525	0.677	<.001	70	view →
COAD	DFS	Tertile	All	0.707	0.826	.002	50	view →
UVM	DFS	Median	II,III,IV	0.400	0.696	.001	43	view →
LGG	DFS	Tertile	All	0.644	0.791	<.001	36	view →
DLBC	DFS	Median	All	0.622	1.000	.014	32	view →
ESCA	OS	Quartile	All	1.000	0.155	.004	27	view →
STAD	OS	Quartile	II,III,IV	0.475	0.675	.027	25	view →
SKCM	OS	Tertile	II,III,IV	0.842	0.650	.012	21	view →
MESO	DFS	Quartile	II,III,IV	0.433	0.255	.017	20	view →
THCA	DFS	Quartile	II,III,IV	0.718	0.948	.006	19	view →
UCEC	OS	Quartile	All	0.836	0.905	.020	16	view →
READ	OS	Quartile	II,III,IV	0.731	0.981	.006	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0044065–KIRC (DFS)

Open the KIRC breakdown →