Regulation of excretion

Across TCGA patient cohorts, RNA activity of the Regulation of excretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACC1, ACOX2, and STC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of excretion activity versus TACC1 in GBM (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TACC1 →	-0.545	-0.216	.008	.003	2	4
BRCA	ACOX2 →	+1.166	+0.799	.006	.001	3	3
BRCA	STC1 →	+1.269	+0.564	<.001	.005	3	3
BRCA	BCDIN3D-AS1 →	+0.357	+0.773	.001	.006	3	3
CCRCC	ZFAND5 →	-0.644	-0.717	.004	.003	3	3
GBM	CADM4 →	-1.291	-0.216	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044062 vs TACC1 — GBM

Explore this scatter interactively →