Regulation of endocrine process

Across TCGA patient cohorts, RNA activity of the Regulation of endocrine process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDC42BPB, FKBP7, and RSU1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endocrine process activity versus CDC42BPB in CCRCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDC42BPB →	+0.267	+0.078	<.001	<.001	3	7
LSCC	FKBP7 →	+0.419	+0.053	<.001	<.001	3	7
BRCA	RSU1 →	+0.373	+0.050	<.001	<.001	3	6
OV	SARM1 →	+0.378	+0.045	.001	.003	3	6
CCRCC	PALM2AKAP2 →	+0.593	+0.081	<.001	<.001	3	6
CCRCC	PARVA →	+0.427	+0.073	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044060 vs CDC42BPB — CCRCC

Explore this scatter interactively →