Positive regulation by host of viral transcription

Across TCGA cell cohorts, RNA activity of the Positive regulation by host of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL16A1, TGFBI, and COL5A1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COL16A1 grouped by Positive regulation by host of viral transcription-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COL16A1 →	-3.524	-0.291	.001	.008	3	6
CNS	TGFBI →	-3.632	-0.414	<.001	.001	3	6
LUNG_NSCLC_LUSC	COL5A1 →	-4.183	-0.378	<.001	.003	3	5
BREAST	TSACC →	+0.679	+0.277	.003	.004	3	5
LUNG_NSCLC_LUSC	F3 →	-4.293	-0.331	.003	.009	3	5
LUNG_NSCLC_LUSC	THBS1 →	-3.639	-0.452	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COL16A1 by Positive regulation by host of viral transcription activity — SOFT_TISSUE

Explore this box plot interactively →