Positive regulation by host of viral transcription

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation by host of viral transcription pathway differs between tumor and matched normal tissue in 8 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

COAD, HNSC, and KIRC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	All	+0.041	<.001	8	view →
HNSC	All	All	+0.037	<.001	8	view →
KIRC	All	All	+0.016	<.001	8	view →
BRCA	All	All	+0.029	<.001	4	view →
CHOL	All	All	+0.045	.001	3	view →
KIRP	All	IV	+0.057	.030	2	view →
STAD	All	All	+0.035	.035	2	view →
PRAD	All	All	+0.031	<.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 8 strongest of 8 lineages.

GO:0043923–COAD

Open the COAD breakdown →