Positive regulation by host of viral transcription

Across TCGA cell cohorts, RNA activity of the Positive regulation by host of viral transcription pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF212, PVRIG, and NCEH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation by host of viral transcription activity versus ZNF212 in BONE (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF212 →	+1.136	+0.457	<.001	<.001	3	6
BLOOD_Lymphoma	PVRIG →	+2.492	+0.294	.004	.001	3	6
OVARY	NCEH1 →	-2.134	-0.878	<.001	.001	3	6
BLOOD_Leukemia	RAPGEF5 →	+1.544	+0.412	<.001	.002	3	6
BLOOD_Lymphoma	CD59 →	-1.704	-0.238	.004	<.001	3	6
BLOOD_Leukemia	DNMT3A →	+1.102	+0.359	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0043923 vs ZNF212 — BONE

Explore this scatter interactively →